Potential for minimal self-replicating systems in a dynamic combinatorial library of equilibrating imines
نویسندگان
چکیده
منابع مشابه
Minimal self-replicating systems.
Minimal self-replicating systems typically consist of three components: a product molecule, and two substrate molecules that become joined to form another product molecule. An important characteristic of self-replicating systems is the ability of the product to catalyze the formation of additional product, resulting in autocatalytic behavior. Recent advances in the area of self-replication have...
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Examples of chemical systems capable of templating and catalysing their own synthesis—self-replicating systems— have begun to appear in the chemical literature over the last 15 years. For the biologist, these systems represent a link with the origin of life—their study can shed light on prebiotic chemical evolution. However, for the synthetic chemist, they represent the ultimate synthetic machi...
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Spontaneous emergence of solid state chirality and mirror symmetry breaking occurred upon crystallization from a small templated dynamic combinatorial library (DCL) of achiral macrocyclic imines, and depended strongly on the nature of library building blocks (amines, aldehydes, template cations and anions) and crystallization temperature.
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Dissipative particle dynamics (DPD) is now a well-established method for simulating soft matter systems. However, its applicability was recently questioned because some investigations showed an upper coarse-graining limit that would prevent the applicability of the method to the whole mesoscopic range. This article aims to reestablish DPD as a truly mesoscopic method by analyzing the problems r...
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ژورنال
عنوان ژورنال: Tetrahedron
سال: 2017
ISSN: 0040-4020
DOI: 10.1016/j.tet.2017.06.045